Unc5a (NM_153131) Mouse Recombinant Protein

Product Specifications

Background

Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Mouse unc-5 netrin receptor A (Unc5a), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Synonyms

MKIAA1976; Unc5h1

Gene ID

107448

UniProt

Q8K1S4

Accession Number mRNA

NM_153131

Chromosomal Location

13 B1

Expression System

HEK293T

Tag

C-MYC/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Molecular Weight

99.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.