Ube2c (NM_026785) Mouse Recombinant Protein
Product Specifications
Background
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse ubiquitin-conjugating enzyme E2C (Ube2c), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
1110015A16Rik; D2Ertd695e
Gene ID
68612
UniProt
Q9D1C1, A2A4Z0
Accession Number mRNA
NM_026785
Chromosomal Location
2 85.27 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
19.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Ube2c
Species
Mouse
Protein ID
NP_081061
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/68612
Uniprot URL
https://www.uniprot.org/uniprot/Q9D1C1
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_026785
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_081061
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