Nlrp10 (NM_175532) Mouse Recombinant Protein

Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (By similarity) . Displays anti-inflammatory activity (By similarity) . Required for immunity against C.albicans infection (PubMed:23071280) . Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection (By similarity) . Contributes to T-cell-mediated inflammatory responses in the skin (PubMed:27221772) . Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (By similarity) . Exhibits both ATPase and GTPase activities (By similarity) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.