Hey2 (NM_013904) Mouse Recombinant Protein
Product Specifications
Background
Transcriptional repressor which functions as a downstream effector of Notch signaling in cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY1 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3.[UniProtKB/Swiss-Prot Function]
Synonyms
BHLHb32; CHF1; Herp1; hesr2; Hrt2
Gene ID
15214
UniProt
Q9QUS4, Q0VGJ1
Accession Number mRNA
NM_013904
Chromosomal Location
10 A4
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
36.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Hey2
Species
Mouse
Protein ID
NP_038932
Overview
Purified recombinant protein of Mouse hairy/enhancer-of-split related with YRPW motif 2 (Hey2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/15214
Uniprot URL
https://www.uniprot.org/uniprot/Q9QUS4
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_013904
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_038932
Curated Selection
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