Ankfy1 (NM_009671) Mouse Recombinant Protein

Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI (3) P) . Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport (By similarity) . Involved in macropinocytosis; the function is dependent on Rab5-GTP.[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Purified recombinant protein of Mouse ankyrin repeat and FYVE domain containing 1 (Ankfy1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug