Foxl2 (NM_012020) Mouse Recombinant Protein
Product Specifications
Background
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. Is a regulator of CYP19 expression. Is a transcriptional repressor of STAR. Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse forkhead box L2 (Foxl2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
AU045128; BPES; Pfrk; PINTO
Gene ID
26927
UniProt
O88470, Q2TVT7
Accession Number mRNA
NM_012020
Chromosomal Location
9 E3.3
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
39.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Foxl2
Species
Mouse
Protein ID
NP_036150
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/26927
Uniprot URL
https://www.uniprot.org/uniprot/O88470
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_012020
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_036150
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