Trim6 (NM_001013616) Mouse Recombinant Protein

Product Specifications

Background

E3 ubiquitin-protein ligase which ubiquitinates MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (PubMed:22328504) . Involved in the synthesis of unanchored K48-linked polyubiquitin chains which interact with and activate the serine/threonine kinase IKBKE, leading to phosphorylation of STAT1 and stimulation of an antiviral response (PubMed:24882218) .[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Mouse tripartite motif-containing 6 (Trim6), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Synonyms

C430046K18Rik; D7Ertd684e

Gene ID

94088

UniProt

Q8BGE7

Accession Number mRNA

NM_001013616

Chromosomal Location

7 55.55 cM

Expression System

HEK293T

Tag

C-MYC/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Molecular Weight

56.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.