Smad7 (NM_001042660) Mouse Recombinant Protein
Product Specifications
Background
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse SMAD family member 7 (Smad7), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
Madh7
Gene ID
17131
UniProt
O35253, B2RPW6
Accession Number mRNA
NM_001042660
Chromosomal Location
18 E3
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
46.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Smad7
Species
Mouse
Protein ID
NP_001036125
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/17131
Uniprot URL
https://www.uniprot.org/uniprot/O35253
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001042660
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001036125
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