Tfcp2l1 (NM_023755) Mouse Recombinant Protein

Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:23942233, PubMed:26321140) . With Klf2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/Stat3 and Wnt/beta-catenin signaling (PubMed:23942238, PubMed:23942233, PubMed:26321140) . Required for normal duct development in the salivary gland and kidney (PubMed:17079272) . Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (PubMed:28577314) . Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, Oxgr1, Ca12, Slc4a1, Aqp6 and IC-specific transcription factor Foxi1 (PubMed:28577314) . Regulates also the expression of Jag1 and subsequent notch signaling in the collecting duct (PubMed:28577314) . Jag1 initiates notch signaling in PCs but inhibits notch signaling in ICs (PubMed:28577314) . Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (PubMed:11073954) . Modulates the placental expression of CYP11A1 (By similarity) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.