Pappa (NM_021362) Mouse Recombinant Protein
Product Specifications
Background
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Isoform 2 cleaves IGFBP-4 very slowly compared to PAPP-A, but its ability to cleave IGFBP-5 is unaffected.[UniProtKB/Swiss-Prot Function]
Synonyms
8430414N03Rik; IGFBP-4ase; PAG1; PAPP-A
Gene ID
18491
UniProt
Q8R4K8
Accession Number mRNA
NM_021362
Chromosomal Location
4 34.14 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
181.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Pappa
Species
Mouse
Protein ID
NP_067337
Overview
Purified recombinant protein of Mouse pregnancy-associated plasma protein A (Pappa), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/18491
Uniprot URL
https://www.uniprot.org/uniprot/Q8R4K8
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_021362
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_067337
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