Smad6 (NM_008542) Mouse Recombinant Protein

Product Specifications

Background

Binds to regulatory elements in target promoter regions (By similarity) . May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding (By similarity) . Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes.[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Mouse SMAD family member 6 (Smad6), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Synonyms

B2b390Clo; Madh6

Gene ID

17130

UniProt

O35182

Accession Number mRNA

NM_008542

Chromosomal Location

9 C

Expression System

HEK293T

Tag

C-MYC/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Molecular Weight

54.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.