Smad6 (NM_008542) Mouse Recombinant Protein
Product Specifications
Background
Binds to regulatory elements in target promoter regions (By similarity) . May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding (By similarity) . Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse SMAD family member 6 (Smad6), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
B2b390Clo; Madh6
Gene ID
17130
UniProt
O35182
Accession Number mRNA
NM_008542
Chromosomal Location
9 C
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
54.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Smad6
Species
Mouse
Protein ID
NP_032568
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/17130
Uniprot URL
https://www.uniprot.org/uniprot/O35182
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_008542
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_032568
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