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GCNT2 (NM_145655) Human Recombinant Protein

Product Specifications

Background

This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Synonyms

BA360O19.2; bA421M1.1; CCAT; CTRCT13; GCNT2C; GCNT5; IGNT; II; NACGT1; NAGCT1; ULG3

Gene ID

2651

UniProt

Q06430, Q8N0V5, Q8NFS9

Accession Number mRNA

NM_145655

Chromosomal Location

6p24.3-p24.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Glycosphingolipid biosynthesis - lacto and neolacto series, Metabolic pathways

Field of Research

Glycosphingolipid biosynthesis - lacto and neolacto series, Metabolic pathways

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Transmembrane

Molecular Weight

46.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

GCNT2

Species

Human

Protein ID

NP_663630

Overview

Recombinant protein of human glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) (GCNT2), transcript variant 3

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/2651

Uniprot URL

https://www.uniprot.org/uniprot/Q06430

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_145655

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_663630

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