LOX (NM_002317) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]
Synonyms
AAT10
Gene ID
4015
UniProt
P28300, D0PNI2
Accession Number mRNA
NM_002317
Chromosomal Location
5q23.1
Expression System
HEK293
Tag
C-DDK/His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
PBS, pH7.4, 10% glycerol
Function
Druggable Genome, Secreted Protein
Molecular Weight
17 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
LOX
Species
Human
Protein ID
NP_002308
Overview
Recombinant protein of N-terminal propeptide (LOXPP) of human lysyl oxidase (LOX), with C-terminal DDK/His tag, expressed in human cells
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4015
Uniprot URL
https://www.uniprot.org/uniprot/P28300
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002317
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002308
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