CD3E (NM_000733) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human CD3e molecule, epsilon (CD3-TCR complex) (CD3E), expressed in human cells
Synonyms
IMD18; T3E; TCRE
Gene ID
916
UniProt
P07766
Accession Number mRNA
NM_000733
Chromosomal Location
11q23.3
Expression System
HEK293
Tag
C-DDK/His
Related Pathways
Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway
Field of Research
Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
PBS, pH7.4, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
14 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CD3E
Species
Human
Protein ID
NP_000724
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/916
Uniprot URL
https://www.uniprot.org/uniprot/P07766
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000733
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000724
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