RON (MST1R) (NM_002447) Human Recombinant Protein
Product Specifications
Background
This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]
Synonyms
CD136; CDw136; NPCA3; PTK8; RON; SEA
Gene ID
4486
UniProt
Q04912
Accession Number mRNA
NM_002447
Chromosomal Location
3p21.31
Expression System
HEK293
Tag
C-DDK/His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
PBS, pH7.4, 10% glycerol
Function
Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane
Molecular Weight
102 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
MST1R
Species
Human
Protein ID
NP_002438
Overview
Purified recombinant protein of human macrophage stimulating 1 receptor (c-met-related tyrosine kinase) (MST1R), transcript variant 1, with C-terminal DDK/His tag, expressed in human cells, 20 µg
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4486
Uniprot URL
https://www.uniprot.org/uniprot/Q04912
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002447
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002438
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