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LGR5 (NM_003667) Human Recombinant Protein

Selected Variant

PH32901M4

Size: 20 µg

Product Specifications

Background

The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Overview

Purified recombinant protein of Homo sapiens leucine-rich repeat containing G protein-coupled receptor 5 (LGR5), residues 447-561aa, with C-terminal Fc tag, expressed in HEK293 cells.

Synonyms

FEX; GPR49; GPR67; GRP49; HG38

Gene ID

8549

UniProt

O75473, A0A0A8K8C7

Accession Number mRNA

NM_003667

Chromosomal Location

12q21.1

Expression System

HEK293

Tag

C-Fc

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

PBS, pH7.4, 10% glycerol

Function

Druggable Genome, GPCR, Transmembrane

Molecular Weight

38 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

LGR5

Species

Human

Protein ID

NP_003658

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/8549

Uniprot URL

https://www.uniprot.org/uniprot/O75473

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_003667

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_003658

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