PD1 (PDCD1) (NM_005018) Human Recombinant Protein

Product Specifications

Background

Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020]

Overview

Purified recombinant protein of Homo sapiens programmed cell death 1 (PDCD1), 25-167aa, with C-terminal DDK/His tag, expressed in HEK293 cells.

Synonyms

CD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; SLEB2

Gene ID

5133

UniProt

Q15116, A0A0M3M0G7

Accession Number mRNA

NM_005018

Chromosomal Location

2q37.3

Expression System

HEK293

Tag

C-DDK/His

Related Pathways

Cell adhesion molecules (CAMs), T cell receptor signaling pathway

Field of Research

Cell adhesion molecules (CAMs), T cell receptor signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

PBS, pH7.4, 10% glycerol

Function

Druggable Genome, Transmembrane

Molecular Weight

31.65

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.