TIM 3 (HAVCR2) (NM_032782) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
Synonyms
CD366; HAVcr-2; KIM-3; SPTCL; Tim-3; TIM3; TIMD-3; TIMD3
Gene ID
84868
UniProt
Q8TDQ0
Accession Number mRNA
NM_032782
Chromosomal Location
5q33.3
Expression System
HEK293
Tag
C-DDK/His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
PBS, pH7.4, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
23 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
HAVCR2
Species
Human
Protein ID
NP_116171
Overview
Purified recombinant protein of human T-cell immunoglobulin mucin receptor 3 (TIM3), with C-terminal DDK/His tag, expressed in human cells, 20 µg
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/84868
Uniprot URL
https://www.uniprot.org/uniprot/Q8TDQ0
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_032782
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_116171
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