B7-1 (CD80) (NM_005191) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
Synonyms
B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; LAB7
Gene ID
941
UniProt
P33681, A0N0P2
Accession Number mRNA
NM_005191
Chromosomal Location
3q13.33
Expression System
HEK293
Tag
C-Fc/His
Related Pathways
Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Graft-versus-host disease, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Viral myocarditis
Field of Research
Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Graft-versus-host disease, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Viral myocarditis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
PBS, pH7.4, 10% glycerol
Function
Druggable Genome, Transcription Factors, Transmembrane
Molecular Weight
51 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CD80
Species
Human
Protein ID
NP_005182
Overview
Purified recombinant protein of human CD80 molecule (CD80), with C-terminal Fc/His tag, expressed in human cells, 20 µg
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/941
Uniprot URL
https://www.uniprot.org/uniprot/P33681
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005191
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005182
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