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Angiopoietin like 4 (ANGPTL4) (NM_139314) Human Recombinant Protein

Product Specifications

Background

This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]

Overview

Purified recombinant protein of human angiopoietin-like 4 (ANGPTL4), transcript variant 1, with C-terminal DDK/His tag, expressed in human cells, 20 µg

Synonyms

ARP4; FIAF; HARP; HFARP; NL2; PGAR; pp1158; TGQTL; UNQ171

Gene ID

51129

UniProt

Q9BY76

Accession Number mRNA

NM_139314

Chromosomal Location

19p13.2

Expression System

HEK293

Tag

C-DDK/His

Related Pathways

PPAR signaling pathway

Field of Research

PPAR signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

PBS, pH7.4, 10% glycerol

Function

Druggable Genome, Secreted Protein

Molecular Weight

18 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

ANGPTL4

Species

Human

Protein ID

NP_647475

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/51129

Uniprot URL

https://www.uniprot.org/uniprot/Q9BY76

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_139314

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_647475

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