ICOS Ligand (ICOSLG) (NM_015259) Human Recombinant Protein

Product Specifications

Background

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity) .[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of human inducible T-cell co-stimulator ligand (ICOSLG), with C-terminal DDK/His tag, expressed in human cells, 20 µg

Synonyms

B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275; GL50; ICOS-L; ICOSL; LICOS

Gene ID

23308

UniProt

O75144, A0N0L8

Accession Number mRNA

NM_015259

Chromosomal Location

21q22.3

Expression System

HEK293

Tag

C-DDK/His

Related Pathways

Cell adhesion molecules (CAMs)

Field of Research

Cell adhesion molecules (CAMs)

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

PBS, pH7.4, 10% glycerol

Function

Transmembrane

Molecular Weight

29 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.