CD137 (TNFRSF9) (NM_001561) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]
Synonyms
4-1BB; CD137; CDw137; ILA
Gene ID
3604
UniProt
Q07011
Accession Number mRNA
NM_001561
Chromosomal Location
1p36.23
Expression System
HEK293
Tag
C-DDK/His
Related Pathways
Cytokine-cytokine receptor interaction
Field of Research
Cytokine-cytokine receptor interaction
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
PBS, pH7.4, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
20 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TNFRSF9
Species
Human
Protein ID
NP_001552
Overview
Purified recombinant protein of human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9), with C-terminal DDK/His tag, expressed in human cells, 20 µg
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/3604
Uniprot URL
https://www.uniprot.org/uniprot/Q07011
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001561
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001552
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