Bone Sialoprotein (IBSP) (NM_004967) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]
Overview
Purified recombinant protein of human integrin-binding sialoprotein (IBSP), with C-terminal DDK/His tag, expressed in human cells.
Synonyms
BNSP; BSP; BSP-II; SP-II
Gene ID
3381
UniProt
P21815
Accession Number mRNA
NM_004967
Chromosomal Location
4q22.1
Expression System
HEK293
Tag
C-DDK/10xHis
Related Pathways
ECM-receptor interaction, Focal adhesion
Field of Research
ECM-receptor interaction, Focal adhesion
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
PBS, pH7.4, 10% glycerol
Function
Druggable Genome, Secreted Protein
Molecular Weight
36 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
IBSP
Species
Human
Protein ID
NP_004958
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/3381
Uniprot URL
https://www.uniprot.org/uniprot/P21815
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004967
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004958
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