Senataxin (SETX) (NM_015046) Human Recombinant Protein
Product Specifications
Background
This gene encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. The protein encoded by this gene contains a DNA/RNA helicase domain at its C-terminal end which suggests that it may be involved in both DNA and RNA processing. Mutations in this gene have been associated with ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4) . [provided by RefSeq, Jul 2008]
Synonyms
ALS4; AOA2; bA479K20.2; SCAN2; SCAR1; Sen1
Gene ID
23064
UniProt
Q7Z333
Accession Number mRNA
NM_015046
Chromosomal Location
9q34.13
Expression System
HEK293
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
57.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SETX
Species
Human
Protein ID
NP_055861
Overview
Purified recombinant protein of Human senataxin (SETX), (L389S) mutant protein, esidues Met1-Phe500, expressed in HEK293 cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/23064
Uniprot URL
https://www.uniprot.org/uniprot/Q7Z333
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_015046
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_055861
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