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HNF1 alpha (HNF1A) (NM_000545) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Synonyms

HNF-1A; HNF1; HNF1alpha; HNF4A; IDDM20; LFB1; MODY3; TCF-1; TCF1

Gene ID

6927

UniProt

P20823, E0YMI7

Accession Number mRNA

NM_000545

Chromosomal Location

12q24.31

Expression System

HEK293

Tag

C-Myc/DDK

Related Pathways

Maturity onset diabetes of the young

Field of Research

Maturity onset diabetes of the young

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors

Molecular Weight

67.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

HNF1A

Species

Human

Protein ID

NP_000536

Overview

Purified recombinant protein of Human HNF1 homeobox A (HNF1A), mutant (C50S), expressed in HEK293 cells, 20ug

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/6927

Uniprot URL

https://www.uniprot.org/uniprot/P20823

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000545

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000536

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