PLA2G12A (NM_030821) Human Recombinant Protein
Product Specifications
Background
Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]) .[supplied by OMIM, Mar 2008]
Overview
Purified recombinant protein of Human phospholipase A2, group XIIA (PLA2G12A), with C-terminal His tag, secretory expressed in HEK293 cells, 50ug
Synonyms
GXII; PLA2G12; ROSSY
Gene ID
81579
UniProt
Q9BZM1, Q542Y6
Accession Number mRNA
NM_030821
Chromosomal Location
4q25
Expression System
HEK293
Tag
C-His
Related Pathways
Alpha-Linolenic acid metabolism, Arachidonic acid metabolism, Ether lipid metabolism, Fc epsilon RI signaling pathway, Glycerophospholipid metabolism, GnRH signaling pathway, Linoleic acid metabolism, Long-term depression, MAPK signaling pathway, Metabolic pathways, Vascular smooth muscle contraction, VEGF signaling pathway
Field of Research
Alpha-Linolenic acid metabolism, Arachidonic acid metabolism, Ether lipid metabolism, Fc epsilon RI signaling pathway, Glycerophospholipid metabolism, GnRH signaling pathway, Linoleic acid metabolism, Long-term depression, MAPK signaling pathway, Metabolic pathways, Vascular smooth muscle contraction, VEGF signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
PBS, pH7.4, 10% glycerol
Function
Druggable Genome, Secreted Protein
Molecular Weight
20 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PLA2G12A
Species
Human
Protein ID
NP_110448
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/81579
Uniprot URL
https://www.uniprot.org/uniprot/Q9BZM1
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_030821
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_110448
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