SRC (NM_005417) Human Recombinant Protein
Product Specifications
Background
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms
ASV; c-SRC; p60-Src; SRC1; THC6
Gene ID
6714
UniProt
P12931
Accession Number mRNA
NM_005417
Chromosomal Location
20q11.23
Expression System
Sf9
Tag
C-His
Related Pathways
Adherens junction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Focal adhesion, Gap junction, GnRH signaling pathway, Tight junction, VEGF signaling pathway
Field of Research
Adherens junction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Focal adhesion, Gap junction, GnRH signaling pathway, Tight junction, VEGF signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris-HCl pH8.0, 150mM NaCl, 20% glycerol
Function
Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Stem cell relevant signaling - JAK/STAT signaling pathway
Molecular Weight
60 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SRC
Species
Human
Protein ID
NP_005408
Overview
Recombinant protein of human v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) (SRC), with N-terminal polyhistidine tag, expressed in sf9 cells.
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/6714
Uniprot URL
https://www.uniprot.org/uniprot/P12931
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005417
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005408
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