DCK (NM_000788) Human Recombinant Protein
Product Specifications
Background
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human deoxycytidine kinase (DCK), full length with N-terminal polyhistidine tag, expressed in sf9 cells.
Synonyms
MGC117410; MGC138632
Gene ID
1633
UniProt
P27707, F5CTF3
Accession Number mRNA
NM_000788
Chromosomal Location
4q13.3
Expression System
Sf9
Tag
N-His
Related Pathways
Purine metabolism, Pyrimidine metabolism
Field of Research
Purine metabolism, Pyrimidine metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris-HCl pH8.0, 150mM NaCl, 20% glycerol
Function
Druggable Genome
Molecular Weight
30 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
DCK
Species
Human
Protein ID
NP_000779
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/1633
Uniprot URL
https://www.uniprot.org/uniprot/P27707
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000788
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000779
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