DCK (NM_000788) Human Recombinant Protein

Product Specifications

Background

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human deoxycytidine kinase (DCK), full length with N-terminal polyhistidine tag, expressed in sf9 cells.

Synonyms

MGC117410; MGC138632

Gene ID

1633

UniProt

P27707, F5CTF3

Accession Number mRNA

NM_000788

Chromosomal Location

4q13.3

Expression System

Sf9

Tag

N-His

Related Pathways

Purine metabolism, Pyrimidine metabolism

Field of Research

Purine metabolism, Pyrimidine metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris-HCl pH8.0, 150mM NaCl, 20% glycerol

Function

Druggable Genome

Molecular Weight

30 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.