TFE3 (NM_006521) Human Recombinant Protein

Product Specifications

Background

This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Overview

Recombinant protein of human transcription factor binding to IGHM enhancer 3 (TFE3), with N-terminal polyhistidine tag, expressed in sf9 cells.

Synonyms

BHLHe33; RCCP2; RCCX1; TFEA

Gene ID

7030

UniProt

P19532, A0A024QZ23

Accession Number mRNA

NM_006521

Chromosomal Location

Xp11.23

Expression System

Sf9

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris-HCl pH8.0, 150mM NaCl, 10%glycerol

Function

Druggable Genome, Transcription Factors

Molecular Weight

62 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.