PARP1 (NM_001618) Human Recombinant Protein
Product Specifications
Background
This gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl) transferase, which modifies various nuclear proteins by poly (ADP-ribosyl) ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human poly (ADP-ribose) polymerase 1 (PARP1), full length, with C-terminal flag tag, expressed in sf9 cells
Synonyms
ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1; PARP; PARP-1; PPOL
Gene ID
142
UniProt
P09874, A0A024R3T8
Accession Number mRNA
NM_001618
Chromosomal Location
1q42.12
Expression System
Sf9
Tag
C-DDK
Related Pathways
Base excision repair
Field of Research
Base excision repair
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris-HCl pH8.0, 150mM NaCl, 10%glycerol
Function
Druggable Genome, Stem cell - Pluripotency, Transcription Factors
Molecular Weight
113 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PARP1
Species
Human
Protein ID
NP_001609
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/142
Uniprot URL
https://www.uniprot.org/uniprot/P09874
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001618
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001609
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