VEGF Receptor 1 (FLT1) (NM_002019) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig) -like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
Synonyms
FLT; FLT-1; VEGFR-1; VEGFR1
Gene ID
2321
UniProt
P17948, L7RSL3
Accession Number mRNA
NM_002019
Chromosomal Location
13q12.3
Expression System
Sf9
Tag
C-DDK
Related Pathways
Cytokine-cytokine receptor interaction, Endocytosis, Focal adhesion
Field of Research
Cytokine-cytokine receptor interaction, Endocytosis, Focal adhesion
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol
Function
Druggable Genome, Protein Kinase, Secreted Protein
Molecular Weight
82.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
FLT1
Species
Human
Protein ID
NP_002010
Overview
Recombinant protein of human fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1), transcript variant 1, residues 27-758aa, with C-terminal DDK tag, expressed in sf9, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/2321
Uniprot URL
https://www.uniprot.org/uniprot/P17948
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002019
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002010
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