MERTK (NM_006343) Human Recombinant Protein

Product Specifications

Background

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP) . [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human c-mer proto-oncogene tyrosine kinase (MERTK), residues 21-505aa, with C-terminal DDK tag, expressed in sf9, 20ug

Synonyms

C-Eyk; c-mer; MER; RP38; Tyro12

Gene ID

10461

UniProt

Q12866

Accession Number mRNA

NM_006343

Chromosomal Location

2q13

Expression System

Sf9

Tag

C-DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol.

Function

Druggable Genome, Protein Kinase, Transmembrane

Molecular Weight

52.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.