MERTK (NM_006343) Human Recombinant Protein
Product Specifications
Background
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP) . [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human c-mer proto-oncogene tyrosine kinase (MERTK), residues 21-505aa, with C-terminal DDK tag, expressed in sf9, 20ug
Synonyms
C-Eyk; c-mer; MER; RP38; Tyro12
Gene ID
10461
UniProt
Q12866
Accession Number mRNA
NM_006343
Chromosomal Location
2q13
Expression System
Sf9
Tag
C-DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol.
Function
Druggable Genome, Protein Kinase, Transmembrane
Molecular Weight
52.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
MERTK
Species
Human
Protein ID
NP_006334
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/10461
Uniprot URL
https://www.uniprot.org/uniprot/Q12866
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_006343
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_006334
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