LYRIC (MTDH) (NM_178812) Human Recombinant Protein
Product Specifications
Background
Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human metadherin (MTDH), residues 70-582aa, with N-terminal His tag, expressed in sf9 cells
Synonyms
3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3
Gene ID
92140
UniProt
Q86UE4, A0A024R9D2
Accession Number mRNA
NM_178812
Chromosomal Location
8q22.1
Expression System
Sf9
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol
Function
Transmembrane
Molecular Weight
56.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
MTDH
Species
Human
Protein ID
NP_848927
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/92140
Uniprot URL
https://www.uniprot.org/uniprot/Q86UE4
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_178812
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_848927
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