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DDR2 (NM_001014796) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. [provided by RefSeq, Aug 2017]

Overview

Recombinant protein of human discoidin domain receptor tyrosine kinase 2 (DDR2), transcript variant 1, residues 22-399aa, with C-terminal DDK tag, expressed in sf9, 20ug

Synonyms

MIG20a; NTRKR3; TKT; TYRO10; WRCN

Gene ID

4921

UniProt

Q16832, A0A024R906

Accession Number mRNA

NM_001014796

Chromosomal Location

1q23.3

Expression System

Sf9

Tag

C-DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol.

Function

Druggable Genome, Protein Kinase, Transmembrane

Molecular Weight

44.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

DDR2

Species

Human

Protein ID

NP_001014796

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/4921

Uniprot URL

https://www.uniprot.org/uniprot/Q16832

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001014796

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001014796

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