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PHGDH (NM_006623) Human Recombinant Protein

Product Specifications

Background

This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]

Synonyms

3-PGDH; 3PGDH; HEL-S-113; NLS; NLS1; PDG; PGAD; PGD; PGDH; PHGDHD; SERA

Gene ID

26227

UniProt

O43175

Accession Number mRNA

NM_006623

Chromosomal Location

1p12

Expression System

Sf9

Tag

C-DDK

Related Pathways

Glycine, serine and threonine metabolism, Metabolic pathways

Field of Research

Glycine, serine and threonine metabolism, Metabolic pathways

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol

Function

Druggable Genome, Stem cell - Pluripotency

Molecular Weight

56.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

PHGDH

Species

Human

Protein ID

NP_006614

Overview

Recombinant protein of human phosphoglycerate dehydrogenase (PHGDH), full length, with C-terminal DDK tag, expressed in sf9, 20ug

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/26227

Uniprot URL

https://www.uniprot.org/uniprot/O43175

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_006623

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_006614

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