HIP55 (DBNL) (NM_014063) Human Recombinant Protein
Product Specifications
Background
Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity) . May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.[UniProtKB/Swiss-Prot Function]
Synonyms
ABP1; HIP-55; HIP55; SH3P7
Gene ID
28988
UniProt
Q9UJU6
Accession Number mRNA
NM_014063
Chromosomal Location
7p13
Expression System
Sf9
Tag
C-DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol
Molecular Weight
48.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
DBNL
Species
Human
Protein ID
NP_054782
Overview
Recombinant protein of human drebrin-like (DBNL), transcript variant 1, full length, with C-terminal DDK tag, expressed in sf9, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/28988
Uniprot URL
https://www.uniprot.org/uniprot/Q9UJU6
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_014063
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_054782
Curated Selection
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