SH3BP5 (NM_004844) Human Recombinant Protein
Product Specifications
Background
Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979) . Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human SH3-domain binding protein 5 (BTK-associated) (SH3BP5), transcript variant 1, full length, with C-terminal DDK tag, expressed in sf9, 20ug
Synonyms
SAB; SH3BP-5
Gene ID
9467
UniProt
O60239
Accession Number mRNA
NM_004844
Chromosomal Location
3p25.1
Expression System
Sf9
Tag
C-DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol
Molecular Weight
50.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SH3BP5
Species
Human
Protein ID
NP_004835
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/9467
Uniprot URL
https://www.uniprot.org/uniprot/O60239
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004844
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004835
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