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TLE3 (NM_005078) Human Recombinant Protein

Product Specifications

Background

This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

Overview

Recombinant protein of human transducin-like enhancer of split 3 (E (sp1) homolog, Drosophila) (TLE3), transcript variant 1, full length, with C-terminal DDK tag, expressed in sf9, 20ug

Synonyms

ESG; ESG3; GRG3; HsT18976

Gene ID

7090

UniProt

Q04726

Accession Number mRNA

NM_005078

Chromosomal Location

15q23

Expression System

Sf9

Tag

C-DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol

Function

Transcription Factors

Molecular Weight

83.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

TLE3

Species

Human

Protein ID

NP_005069

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/7090

Uniprot URL

https://www.uniprot.org/uniprot/Q04726

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_005078

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_005069

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