TLE3 (NM_005078) Human Recombinant Protein
Product Specifications
Background
This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
Synonyms
ESG; ESG3; GRG3; HsT18976
Gene ID
7090
UniProt
Q04726
Accession Number mRNA
NM_005078
Chromosomal Location
15q23
Expression System
Sf9
Tag
C-DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol
Function
Transcription Factors
Molecular Weight
83.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TLE3
Species
Human
Protein ID
NP_005069
Overview
Recombinant protein of human transducin-like enhancer of split 3 (E (sp1) homolog, Drosophila) (TLE3), transcript variant 1, full length, with C-terminal DDK tag, expressed in sf9, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/7090
Uniprot URL
https://www.uniprot.org/uniprot/Q04726
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005078
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005069
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