KDM5A (NM_001042603) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013]

Overview

Purified recombinant protein of Human lysine (K) -specific demethylase 5A (KDM5A), full length, with C-terminal DDK tag, expressed in sf9 insect cells

Synonyms

RBBP-2; RBBP2; RBP2

Gene ID

5927

UniProt

P29375

Accession Number mRNA

NM_001042603

Chromosomal Location

12p13.33

Expression System

Sf9

Tag

C-DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol.

Function

Druggable Genome

Molecular Weight

192 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.