VEGF Receptor 2 (KDR) (NM_002253) Human Recombinant Protein
Product Specifications
Background
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]
Synonyms
CD309; FLK1; VEGFR; VEGFR2
Gene ID
3791
UniProt
P35968
Accession Number mRNA
NM_002253
Chromosomal Location
4q12
Expression System
Sf9
Tag
C-DDK
Related Pathways
Cytokine-cytokine receptor interaction, Endocytosis, Focal adhesion, VEGF signaling pathway
Field of Research
Cytokine-cytokine receptor interaction, Endocytosis, Focal adhesion, VEGF signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol.
Function
Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane
Molecular Weight
83.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
KDR
Species
Human
Protein ID
NP_002244
Overview
Purified recombinant protein of Human kinase insert domain receptor (a type III receptor tyrosine kinase) (KDR), residues 20-764aa, with C-terminal DDK tag, expressed in sf9, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/3791
Uniprot URL
https://www.uniprot.org/uniprot/P35968
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002253
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002244
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