VEGF Receptor 2 (KDR) (NM_002253) Human Recombinant Protein

Product Specifications

Background

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]

Overview

Purified recombinant protein of Human kinase insert domain receptor (a type III receptor tyrosine kinase) (KDR), residues 834–1162 aa, with C-terminal DDK tag, expressed in sf9, 20ug

Synonyms

CD309; FLK1; VEGFR; VEGFR2

Gene ID

3791

UniProt

P35968

Accession Number mRNA

NM_002253

Chromosomal Location

4q12

Expression System

Sf9

Tag

C-DDK

Related Pathways

Cytokine-cytokine receptor interaction, Endocytosis, Focal adhesion, VEGF signaling pathway

Field of Research

Cytokine-cytokine receptor interaction, Endocytosis, Focal adhesion, VEGF signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol.

Function

Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane

Molecular Weight

37.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.