TTI1 (NM_014657) Human Recombinant Protein
Product Specifications
Background
Regulator of the DNA damage response (DDR) . Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC) . Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.[UniProtKB/Swiss-Prot Function]
Synonyms
KIAA0406; smg-10
Gene ID
9675
UniProt
O43156
Accession Number mRNA
NM_014657
Chromosomal Location
20q11.23
Expression System
Sf9
Tag
C-DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol
Molecular Weight
121.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TTI1
Species
Human
Protein ID
NP_055472
Overview
Purified recombinant protein of Human Tel2 interacting protein 1 homolog (S. pombe) (TTI1), full length, with C-terminal DDK tag, expressed in sf9, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/9675
Uniprot URL
https://www.uniprot.org/uniprot/O43156
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_014657
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_055472
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