RIP3 (RIPK3) (NM_006871) Human Recombinant Protein
Product Specifications
Background
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]
Synonyms
RIP3
Gene ID
11035
UniProt
Q9Y572
Accession Number mRNA
NM_006871
Chromosomal Location
14q12
Expression System
Sf9
Tag
N-GST
Related Pathways
Cytosolic DNA-sensing pathway
Field of Research
Cytosolic DNA-sensing pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris-HCl, pH7.4, 20mM Imidazole, 0.3mM DTT, 10% glycerol
Function
Druggable Genome, Protein Kinase
Molecular Weight
56.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
RIPK3
Species
Human
Protein ID
NP_006862
Overview
Purified recombinant protein of mutant (K50A) of Human receptor-interacting serine-threonine kinase 3 (RIPK3, K50A mutant), full length, with N-terminal GST and C-terminal His tag, expressed in sf9, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/11035
Uniprot URL
https://www.uniprot.org/uniprot/Q9Y572
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_006871
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_006862
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS2054806-01 0.1 mL
APC/CY7-Linked Polyclonal Antibody to Thy1 Cell Surface Antigen (Thy1)
Ask
View Details