Ataxin 3 (ATXN3) (NM_004993) Human Recombinant Protein
Product Specifications
Background
Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG) n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2016]
Synonyms
AT3; ATX3; JOS; MJD; MJD1; SCA3
Gene ID
4287
UniProt
P54252
Accession Number mRNA
NM_004993
Chromosomal Location
14q32.12
Expression System
Sf9
Tag
C-DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol
Function
Druggable Genome, Transcription Factors
Molecular Weight
41.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ATXN3
Species
Human
Protein ID
NP_004984
Overview
Purified recombinant protein of Human ataxin 3 (ATXN3), transcript variant reference, full length, with with C-terminal DDK tag, expressed in sf9, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4287
Uniprot URL
https://www.uniprot.org/uniprot/P54252
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004993
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004984
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