Parathyroid Hormone (PTH) (NM_000315) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Overview

Purified recombinant protein of Human parathyroid hormone (PTH), Ser32-Gln115, with N-terminal His-Trx tag, expressed in E. coli, 50ug

Synonyms

FIH1; PTH1

Gene ID

5741

UniProt

P01270

Accession Number mRNA

NM_000315

Chromosomal Location

11p15.3

Expression System

E. coli

Tag

N-His-Trx

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

PBS, 10% glycerol

Function

Druggable Genome, Secreted Protein

Molecular Weight

30.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.