Parathyroid Hormone (PTH) (NM_000315) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Synonyms
FIH1; PTH1
Gene ID
5741
UniProt
P01270
Accession Number mRNA
NM_000315
Chromosomal Location
11p15.3
Expression System
E. coli
Tag
N-His-Trx
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
PBS, 10% glycerol
Function
Druggable Genome, Secreted Protein
Molecular Weight
30.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PTH
Species
Human
Protein ID
NP_000306
Overview
Purified recombinant protein of Human parathyroid hormone (PTH), Ser32-Gln115, with N-terminal His-Trx tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5741
Uniprot URL
https://www.uniprot.org/uniprot/P01270
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000315
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000306
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