BCL2 (NM_000633) Human Recombinant Protein

Product Specifications

Background

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Overview

Purified recombinant protein of Human B-cell CLL/lymphoma 2 (BCL2), nuclear gene encoding mitochondrial protein, transcript variant alpha, Met1-Lys218, with C-terminal His tag, expressed in E. coli, 50ug

Synonyms

Bcl-2; PPP1R50

Gene ID

596

UniProt

P10415, A0A024R2B3

Accession Number mRNA

NM_000633

Chromosomal Location

18q21.33

Expression System

E. coli

Tag

C-His

Related Pathways

Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Focal adhesion, Neurotrophin signaling pathway, Pathways in cancer, Prostate cancer, Small cell lung cancer

Field of Research

Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Focal adhesion, Neurotrophin signaling pathway, Pathways in cancer, Prostate cancer, Small cell lung cancer

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, 150mM NaCl, 10% glycerol.

Function

Druggable Genome, ES Cell Differentiation/IPS, Stem cell - Pluripotency, Transmembrane

Molecular Weight

24.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.