PSMA1 (NM_002786) Human Recombinant Protein
Product Specifications
Background
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
Synonyms
HC2; HEL-S-275; NU; PROS30
Gene ID
5682
UniProt
P25786
Accession Number mRNA
NM_002786
Chromosomal Location
11p15.2
Expression System
E. coli
Tag
N-His
Related Pathways
Proteasome
Field of Research
Proteasome
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol
Function
Druggable Genome, Protease
Molecular Weight
28.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PSMA1
Species
Human
Protein ID
NP_002777
Overview
Recombinant protein of human proteasome (prosome, macropain) subunit, alpha type, 1 (PSMA1), transcript variant 2, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5682
Uniprot URL
https://www.uniprot.org/uniprot/P25786
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002786
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002777
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