MTHFD2 (NM_001040409) Human Recombinant Protein
Product Specifications
Background
This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009]
Synonyms
Methylenetetrahydrofolate dehydro; methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase; methylene tetrahydrofolate dehydrogenase 2; NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase; NMDMC
Gene ID
10797
UniProt
P13995
Accession Number mRNA
NM_001040409
Chromosomal Location
2p13.1
Expression System
E. coli
Tag
N-His
Related Pathways
Glyoxylate and dicarboxylate metabolism, Metabolic pathways, One carbon pool by folate
Field of Research
Glyoxylate and dicarboxylate metabolism, Metabolic pathways, One carbon pool by folate
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 100 mM Arg
Function
Druggable Genome
Molecular Weight
37.895 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
MTHFD2
Species
Human
Protein ID
NP_001035499
Overview
Purified recombinant protein of Homo sapiens methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (MTHFD2), nuclear gene encoding mitochondrial protein, tra, residues 103-350aa, with N-terminal HIS tag, expressed in E.Coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/10797
Uniprot URL
https://www.uniprot.org/uniprot/P13995
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001040409
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001035499
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