MGMT (NM_002412) Human Recombinant Protein
Product Specifications
Background
Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O (6) -alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015]
Overview
Recombinant protein of human O-6-methylguanine-DNA methyltransferase (MGMT), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Synonyms
Methylguanine-DNA methyltransferase; O-6-methylguanine-DNA methyltransferase; O6-methylguanine-DNA methyltransferase; OTTHUMP00000020741
Gene ID
4255
UniProt
P16455, B4DEE8
Accession Number mRNA
NM_002412
Chromosomal Location
10q26.3
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl
Function
Druggable Genome
Molecular Weight
26.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
MGMT
Species
Human
Protein ID
NP_002403
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4255
Uniprot URL
https://www.uniprot.org/uniprot/P16455
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002412
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002403
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