XRCC3 (NM_005432) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human X-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3), transcript variant 2, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Synonyms
CMM6
Gene ID
7517
UniProt
O43542, Q53XC8
Accession Number mRNA
NM_005432
Chromosomal Location
14q32.33
Expression System
E. coli
Tag
N-His
Related Pathways
Homologous recombination
Field of Research
Homologous recombination
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl
Function
Druggable Genome
Molecular Weight
37.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
XRCC3
Species
Human
Protein ID
NP_005423
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/7517
Uniprot URL
https://www.uniprot.org/uniprot/O43542
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005432
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005423
Frequently Asked Questions
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